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Advanced genetic sequencing for cancer patients would now become more affordable and easily accessible, with the newly announced collaboration between GenepoweRx, India’s most trusted Genetic Testing company, and Onco.com, India’s leading patient-centric cancer care management platform. These two well-known names in their industries have agreed to work together in carrying out advanced cancer genomics test …

GenepoweRx and Onco.com sign collaboration agreement to bring world-class affordable advanced gene sequencing technology for cancer patients to India. Read More »

A recent randomized study suggests that Pharmacogenomics testing could be used effectively to customize postoperative pain medicine following total joint replacement. The results of this study, which included 107 patients, were published in The Journal of Arthroplasty. Pharmacogenomics testing was performed on the patients for about 16 genetic variants, which would affect the pharmacodynamics and …

Customization of postoperative pain medication with Pharmacogenomics reduces pain levels Read More »

A recent study published in the Cancer Journal established that chemosensitivity assay profiling is a promising tool which can be used for guiding treatment in advanced pancreatic adenocarcinoma (PDAC) patients. This prospective study aimed to establish chemosensitivity assay as a cutting edge approach to guide treatment in patients with metastatic PDAC. The study included 70 …

Chemosensitivity assay-a promising tool for guiding therapy in Pancreatic adenocarcinoma Read More »

A latest study found an intronic variant (rs6667912) located within TMEM9 that was significantly associated with clinical statin-associated muscle symptoms (SAMS). The study was published in the journal – Circulation: Genomic and Precision Medicine. Statin therapies are known to frequently show adverse events like SAMS. This double-blind, randomized, placebo controlled clinical trial was conducted to …

New variants associated with statin-associated muscle symptoms are identified Read More »

Genetics play a huge role in determining disease activity and treatment response. In this era of precision medicine, genotyping has become extremely important to identify the safest, effective, and cost-effective treatment. Methotrexate(MTX), a conventional synthetic DMARD, is a potent anti-inflammatory and antiproliferative drug and the gold standard for the treatment of RA. However, around 30-40 …

Pharmacogenomics of methotrexate in patients with Rheumatoid arthritis – Current Knowledge and Challenges Read More »

Diabetes mellitus has emerged as a major public health epidemic in the 21st century. It is predicted that the worldwide prevalence of diabetes will become double from 171 million cases in 2000 to 366 million in 2030. India ranks the highest with respect to diabetes prevalence. Antidiabetic drugs is the cornerstone of diabetes management. The …

Role of Pharmacogenomics in Diabetes Read More »

Thyroid hormones play an integral role in our physiology – they regulate metabolism, cardiovascular and bone health, neurological functions, and body growth. Aberrations in thyroid hormone levels impact almost all major body systems. Thus, early diagnosis and management of thyroid disorders is extremely important. Precision medicine is vital to determine specific environmental and genetic factors …

Hyperthyroidism and Precision Medicine: Diagnostic Issues Read More »

The outcomes of breast cancer chemotherapeutic management, including response and incidence of adverse events, differ even in patients with similar subtypes, stages, and grades. This variation can be attributed to factors like patient’s age, diet, alcohol use, smoking, menopausal state, other medications, as well as genetic factors. This article discusses the toxicity and adverse events …

Pharmacogenomic Evaluation of Chemotherapy Toxicity in Breast Cancer Read More »

A 60-year-old man was referred to us for uncontrolled hypercholesterolemiaHypercholesterolemia, or hyperlipidemia refers to high cholesterol levels in the blood. If this condition is not controlled, plaque can accumulate in the blood vessels. This can obstruct blood supply to various parts of the body; if your heart or brain doesn’t get enough blood supply, it …

Patient Story – A 60-year-old with uncontrolled Hypercholesterolemia Read More »