ATGC – General Roundup – Jan23

DNA methylation alterations as potential biomarkers in systemic lupus erythematosus diagnosis

A recent study suggests that DNA methylation alterations of genes like IFI44L, FOXP3, and MX1 have the potential to be Systemic Lupus Erythematosus (SLE) biomarkers. The results of this study were published in the journal, Lupus.

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Germline mutations and mismatch repair genes implicated in prostate cancer

A recent study revealed evidence on the genetic basis of prostate cancer (PCa) predisposition and the importance of germline genetic testing for patients with a positive family history of PCa or men with high-risk or metastatic disease. A systemic review was conducted and the results of this study were published in the journal, Prostate Cancer and Prostatic Diseases.

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Heterozygous variants in BRCA1 and BRCA2 and mismatch repair genes cause cancer risk in children

A recent study has shown that heterozygous pathogenic germline variants in BRCA1, BRCA2, and mismatch repair genes attribute to cancer risk with reduced penetrance in children and young adults. The results of this study were published in the Journal of the National Cancer Institute.

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