November 2022

According to a clinical trial published in The Lancet. Oncology – it was found that Olaparib was associated with reduced pain burden and better-preserved health-related quality of life (HRQOL) in men with metastatic castration-resistant prostate cancer. This was an open-label, randomised, phase 3 study was performed to assess pain and HRQOL measures of olaparib tablets. …

Olaparib improves pain and health-related quality of life in metastatic prostate cancer Read More »

According to a latest study, use of veledimex (VDX)-regulatable interleukin-12 (IL-12) gene therapy combined with immune checkpoint inhibition is safe in recurrent glioblastoma (rGBM). An update of this phase I trial was published in the journal Neuro-Oncology. VDX-regulatable IL-12 gene therapy has shown tumor infiltration of CD8+ T cells, encouraging survival, but also up-regulation of …

Veledimex-regulatable interleukin-12 gene therapy combined with immune checkpoint inhibition is safe in recurrent glioblastoma Read More »

A recent trial found that pharmacogenomic testing for drug-gene interactions in patients with Major Depressive Disorder (MDD) reduced prescription of medications with predicted drug-gene interactions compared with usual care. The results of this study were published in the Journal of the American Medical Association (JAMA). The current practice of selecting effective antidepressants for MFF has …

Pharmacogenomic Testing Reduces the Need for Prescription Medicines in Major Depressive Disorder Read More »

According to a latest report, ibrutinib-rituximab (IR) therapy offers superior progression free survival (PFS) than fludarabine, cyclophosphamide, and rituximab (FCR) in patients with immunoglobulin heavy chain variable region (IGHV) gene mutated or unmutated chronic lymphocytic leukemia (CLL). This was an updated report from the E1912 trial published in the journal, Blood (American Society of Hematology). …

Ibrutinib-rituximab therapy is superior to gold standard therapy for CLL Read More »

Surgery, chemotherapy, and radiation therapy have been the cornerstones of cancer treatment for many years. These continue to be the mainstream treatment methods; however, new categories of treatment have recently helped physicians around the world paint a different picture of cancer treatment for people. Over the past decade, immunotherapy, has become what many call the …

Update on Chimeric Antigen Receptor (CAR) T-cell Therapy Read More »

Familial Adenomatous Polyposis (FAP) is a rare, inherited condition that affects the gastrointestinal tract. Diagnosis is made when 100 or more adenomatous colonic polyps develop. It is caused by a defect in the gene called the adenomatous polyposis coli (APC) gene. It is mostly inherited directly from a parent, but there is a 25 to …

Understanding the Genetics of Familial Adenomatous Polyposis (FAP) Read More »

Understanding how the human mind works has always been intriguing to the medical fraternity. It’s over a decade now that psychiatric genetics has taken a strong foothold in terms of gaining an insight into the heritability aspect of mental disorders. Almost all the major psychiatric disorders have a heritable component to it. Psychiatric disorders tend …

Role of Genetics in Psychiatric Disorders Read More »

Among the various types of cancers, one of the most prevalent ones is breast cancer. Although it can be cured completely if detected in the initial stages, there is still a lot of awareness that is required among the people. Breast cancer may occur due to various causes, but about 5-10% cases are hereditary. There …

Guidelines for Genetic Testing for Hereditary Breast Cancer Read More »

A BREAST LUMP IS PAINLESS, DOESN’T MEAN IS HARMLESS “I had a breast lump, it didn’t hurt, so I didn’t bother…” Above were the lines of a patient who came to my OPD a few days back with a complaint of pain in her breast. Upon examination we found that she had a big lump …

Patient Story Read More »