All ATGC article

Certain genes interact with total folate consumption and impact colorectal cancer risk

A recent study found evidence that suggested gene expression may interact with folate consumption to alter colorectal cancer (CRC) risk. The results of this study were published in Scientific Reports. The study aimed to investigate interactions between folate consumption and predicted gene expression on colorectal cancer risk across the genome. For genes including glutathione S-Transferase …

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Aerobic training and vitamin D supplementation inhibit gene expression of inflammation-related factors

A recent study found that a combination of aerobic training (AT) and vitamin D (Vit D) may enhance the lipid profile and liver enzymes. In comparison to AT or Vit D alone, this can tip the balance in favour of inflammation inhibition by downregulating gene expression of inflammation-related factors. The results of this study were …

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Genes Linked to Abnormal Bone Density and Fracture

A person’s DNA holds the key to their genetic predisposition to diseases. Many diseases have a underlying genetic cause, if it is identified, it is far simpler to have an approach towards correct, targeted treatments. Recent research has made it easier to identify genes that cause abnormal bone density and fractures. Bone mass density (BMD) …

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Role of Genetics in Aromatic L-amino Acid Decarboxylase (AADC) Deficiency

Aromatic L-amino acid decarboxylase (AADC) deficiency is a very rare genetic disorder, marked by decreased activity of the enzyme, aromatic L-amino acid carboxylase. This gene is responsible for synthesis of neurotransmitters, mainly dopamine and serotonin, that helps in communicating between the neurons in central nervous system. Babies born with this condition appears to be normal …

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Effect of Genetics on Nutritional Requirements

Human genome and nutrition have a bilateral relationship. The genes of an individual determine the nutrient status, metabolic response, and susceptibility to diet-dependent or related health disorders. On the other hand, nutrients regulate transcription factors that modify the gene expression, thus, adjust the metabolic responses at molecular level. One of the major causes for the …

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Do Genetic Variants Influence Effectiveness of Exercise?

Physique is quiet a noticeable trait. It has been observed that some people require a strenuous exercise regimen, diet, and so on to achieve a desired physique or body, whereas others achieve the same body with minimal effort. This is because genes play an important role in the exercise outcomes. Studies have found that genes …

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Olaparib improves pain and health-related quality of life in metastatic prostate cancer

According to a clinical trial published in The Lancet. Oncology – it was found that Olaparib was associated with reduced pain burden and better-preserved health-related quality of life (HRQOL) in men with metastatic castration-resistant prostate cancer. This was an open-label, randomised, phase 3 study was performed to assess pain and HRQOL measures of olaparib tablets. …

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Veledimex-regulatable interleukin-12 gene therapy combined with immune checkpoint inhibition is safe in recurrent glioblastoma

According to a latest study, use of veledimex (VDX)-regulatable interleukin-12 (IL-12) gene therapy combined with immune checkpoint inhibition is safe in recurrent glioblastoma (rGBM). An update of this phase I trial was published in the journal Neuro-Oncology. VDX-regulatable IL-12 gene therapy has shown tumor infiltration of CD8+ T cells, encouraging survival, but also up-regulation of …

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Pharmacogenomic Testing Reduces the Need for Prescription Medicines in Major Depressive Disorder

A recent trial found that pharmacogenomic testing for drug-gene interactions in patients with Major Depressive Disorder (MDD) reduced prescription of medications with predicted drug-gene interactions compared with usual care. The results of this study were published in the Journal of the American Medical Association (JAMA). The current practice of selecting effective antidepressants for MFF has …

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Ibrutinib-rituximab therapy is superior to gold standard therapy for CLL

According to a latest report, ibrutinib-rituximab (IR) therapy offers superior progression free survival (PFS) than fludarabine, cyclophosphamide, and rituximab (FCR) in patients with immunoglobulin heavy chain variable region (IGHV) gene mutated or unmutated chronic lymphocytic leukemia (CLL). This was an updated report from the E1912 trial published in the journal, Blood (American Society of Hematology). …

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