Aerobic training and vitamin D supplementation inhibit gene expression of inflammation-related factors

A recent study found that a combination of aerobic training (AT) and vitamin D (Vit D) may enhance the lipid profile and liver enzymes. In comparison to AT or Vit D alone, this can tip the balance in favour of inflammation inhibition by downregulating gene expression of inflammation-related factors. The results of this study were published in BMC Endocrine Disorders.

The study included 40 males with type 2 diabetes mellitus (T2DM) who were randomly assigned to 4 groups: AT+vitamin D supplementation (AT+Vit D), AT+placebo (AT), Vit D supplementation (Vit D), and control+placebo (C) for 8 weeks.

At the end of 8 weeks, the results showed significant favor towards AT+Vit D when compared to other groups. Also, the gene expressions were downregulated significantly in AT+Vit D, AT, and Vit D, while upregulated in C. Further, compared to individual AT or Vit D, AT+Vit D significantly downregulated gene expression of inflammation-related factors. As a result, AT+Vit D may be regarded as a suitable treatment for T2DM.

Therefore, AT+Vit D may be considered appropriate therapy for managing T2DM.

Source

• Hoseini R, Rahim HA, Ahmed JK. Decreased inflammatory gene expression accompanies the improvement of liver enzyme and lipid profile following aerobic training and vitamin D supplementation in T2DM patients. BMC Endocr Disord. 2022 Oct 8;22(1):245. doi:10.1186/s12902-022-01152-x. PMID: 36209084; PMCID: PMC9547373. https://pubmed.ncbi.nlm.nih.gov/36209084/