A recent study has shown that EPHX1 polymorphisms are associated with the risk of pre-eclampsia. The results of this study were published in the Journal of Maternal-Fetal & Neonatal Medicine.
A meta-analysis of 14 studies was conducted retrieved from web databases including 1784 pre-eclampsia patients and 2466 healthy women. Statistically significant associations between the EPHX1 rs1051740 and pre-eclampsia were noted in Caucasians. Also, a statistically significant association between EPHX1 rs2234922 polymorphism and pre-eclampsia was found in Middle Easterners.
Thus, this study concluded that EPHX1 rs1051740 and EPHX1 rs2234922 are significantly associated with the risk of pre-eclampsia in Caucasian and Middle Eastern populations respectively.
Zhao, G., Liu, J., & Meng, T. (2022). Oxidative stress-related genes (EPHX1 and MnSOD) polymorphism and risk of pre-eclampsia: a meta-analysis. The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 35(25), 5526–5538. https://pubmed.ncbi.nlm.nih.gov/33586574/