Single nucleotide polymorphism is associated with ovarian cancer risk

According to a recent study, it was found that Fok1 rs2228570 (single nucleotide polymorphism) is closely associated with ovarian cancer (OC) risk. The results of the study were published in the journal, Cancer Medicine.

A systematic review and network meta-analysis were conducted to search different databases to summarise the association between single nucleotide polymorphism (SNP) and OC published throughout April 2021. The most appropriate gene model was selected using rank probability resulting from network meta-analysis and Thakkinstian’s algorithm.

A total of 63 genes and 92 SNPs were included in the study. After carefully comparing with other selected genes, Fok1 rs2228570 was found to be likely the dominant risk factor in the development of ovarian cancer.

Therefore, the study demonstrated a close association between Fok1 r2228570 and the development of ovarian cancer with the dominant gene model as the most appropriate model to determine OC susceptibility.

Source:

Hu J, Xu Z, Ye Z, et al. The association between single nucleotide polymorphisms and ovarian cancer risk: A systematic review and network meta-analysis. Cancer Med. 2023 Jan;12(1):541-556. https://pubmed.ncbi.nlm.nih.gov/35637613/