Omega-3 fatty acid is inversely related to inflammatory gene expression in Multiple Sclerosis

The findings of a recent study suggest that blood omega-3 fatty acid (FA) is inversely related to inflammatory gene expression (IGE) inn multiple sclerosis (MS).

The results of the study were published in the journal, Nutrients. It included 1353 participants from 13 cohort between the time frame of 3 to 144 weeks. The results obtained were assessed based on the criteria of Expanded Disability Status Scale (EDSS). Various parameters were looked into such as omega-3 polyunsaturated fatty acids (PUFA), docosahexaenoic acid (DHA), α-linolenic acid, and eicosapentaenoic acid (EPA) with EDSS and inflammatory gene expression, tumor necrosis factor-alpha, interleukins (IL-1, IL-6, IL-8).

The results showed an inverse relationship between DHA and EDSS scores. Also, omega-3 FA concentrations were also found to be inversely related to IGE and EDSS scores, showing that they maybe responsible for the diagnosis, prognosis, and management of MS.

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Source: Ghasemi Darestani N, Bahrami A, Mozafarian MR, Esmalian Afyouni N, Akhavanfar R, Abouali R, Moradian A, Lorase S. Association of Polyunsaturated Fatty Acid Intake on Inflammatory Gene Expression and Multiple Sclerosis: A Systematic Review and Meta-Analysis. Nutrients. 2022 Nov 2;14(21):4627. doi: 10.3390/nu14214627. PMID: 36364885; PMCID: PMC9656750. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9656750/.