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Best Drug for all Chronic Conditions

A disease or condition that usually lasts for 3 months or longer and may eventually get worse with time is defined as a chronic disease. Chronic diseases tend to occur in older adults and can usually be controlled but not cured. The most common types of chronic disease are cancer, heart disease, stroke, diabetes, and arthritis.

Chronic diseases usually begin in middle age and continue to manifest in old age.

Current advances in pharmacogenomic studies enable the doctor in making the right decision for treatment to ensure safety of the patient by closely understanding an individual’s gene information and how their body responds to certain drugs.

Unhealthy Lifestyle – a Risk Factor for Chronic Diseases

Chronic diseases, also called as noncommunicable diseases (NCDs), tend to develop during middle age due to long exposure to unhealthy lifestyle routine that involves use of tobacco, alcohol consumption, lack of physical activity or lack of proper nutrition, instead consuming food rich in high saturated fats, sugars, salts, processed and canned foods.

These kinds of lifestyle habits can produce undesired results known as lifestyle disorders. Some of the examples of lifestyle disorders include:

  • Diabetes
  • Obesity
  • High blood pressure
  • High cholesterol
  • Chronic Obstructive Pulmonary Disorder (COPD)
  • Asthma
  • Arthritis
  • Lung cancer
  • Chronic Kidney disease
  • Cardiovascular (heart) disease
  • Immune mediated diseases
  • Metabolic diseases
  • Lung cancer
  • Depression

All these diseases can occur independently, but are also interconnected with each other. This is because the risk factors share similarities among other diseases. Sometimes, the risk factors are frequently undiagnosed or inadequately managed in health services designed to treat acute conditions.

Treatment of Chronic Conditions

A chronic condition usually lasts for a long time and cannot be completely cured. Most of these conditions can be improved via diet, exercise, and healthy lifestyle habits, in addition to medicines.

Mediation for chronic conditions is done by not just taking in one medicine, but multiple medicines. Multiple medicines are called as polypharmacy. Polypharmacy can be defined as – regular usage of at least five medications. This is common in older adults mostly, sometimes in the younger population as well with multimorbidity, as more than one medicine is required to treat each condition.

Multiple medicines are required as more than one chronic condition co-exist. In-take of multiple medicines increases the risk of undesired (adverse) outcomes in the long run.

Problems associated with polypharmacy includes adverse outcomes such as:

  • Mortality
  • Sudden collapse
  • Adverse drug reactions (undesired side effects)
  • Increased length of hospital stays
  • Readmission to hospital soon after discharge
  • Increased expenses
  • Non-adherence

The risk of adverse effects and harm increases with increasing number of medications.

Sometimes prolonged suffering with chronic illnesses can cause an individual to undergo stress and depression that can interfere with successful treatment of the chronic condition.

Precision Medicine in treating Chronic Conditions

Precision medicine is a new advancement of the pharmacogenomics. As most of the chronic conditions have both genetic and environmental factors involved, uncovering novel disease insights by pharmacogenomic testing guides doctors to identify drug targets associated with the disease.

It also utilises biomarkers that predict drug responses in an individual. This information on the whole can help doctors tailor the best possible patient treatment available for them.

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FAQ's :

Pharmacogenomic testing are like diagnostic tests that help the doctor to identify future possibilities of a chronic condition, while also treating one. They can warn and guide the patient to avoid risks and manage the medical situation.

An individual’s gene can give a lot of information that helps to determine their response to certain drugs and which ones to avoid or even how to adjust the dose of a medication. These insights into a patient’s genes enable the doctor to tailor the best drugs for your condition.

Chronic condition can cause a great deal of stress and depression. Some of the tips to cope living with a chronic condition include:
•   Find information on how to live with physical effects of the illness
•   Learn how to deal with treatments and its side effects
•   Find an emotional support group (can be family and friends)
•   Clearly communicate with your doctors
•   Engage with people who are dealing with similar issues (read their stories on how they coped)
•   Try to maintain emotional balance to cope with negative feelings
•   Try to maintain a positive image and practice self-care
•   Get help as soon as symptoms of depression appear

References:

  1. LIFESTYLE DISEASES: An Economic Burden on the Health Services. United Nations. https://www.un.org/en/chronicle/article/lifestyle-diseases-economic-burden-health-services Accessed on 15-07-2022
  1. Chronic illness. Better Health Channel. https://www.betterhealth.vic.gov.au/health/healthyliving/chronic-illness Accessed on 15-07-2022
  1. Medication Habits to Manage Chronic Conditions. Winchester Hospital. https://www.winchesterhospital.org/health-library/article?id=662165 Accessed on 15-07-2022
  1. Chronic Care, Prescription Drugs, And More. Health Affairs. https://www.healthaffairs.org/doi/10.1377/hlthaff.2018.0790 Accessed on 15-07-2022
  1. About Chronic Conditions. Centers for Disease Control and Prevention. https://www.cdc.gov/chronicdisease/about/index.htm Accessed on 15-07-2022
  1. Chronic Disease. National Cancer Institute. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/chronic-disease Accessed on 15-07-2022
  1. Lifestyle and Related Risk Factors for Chronic Diseases. National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK2290/ Accessed on 15-07-2022
  1. Occupational lifestyle diseases: An emerging issue. National Library of Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862441/ Accessed on 15-07-2022
  1. Chronic Illness and Depression. Cleveland Clinic. https://my.clevelandclinic.org/health/articles/9288-chronic-illness-and-depression Accessed on 15-07-2022

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