Treatments Focus

SLE/ Rheumatoid Arthritis

Persistent pain in the joints even at a young age can make wonder and doubt if they are suffering from arthritis. Symptoms such as fatigue, stiffness and swelling of the joints can be similar to different diseased conditions and requires thorough check-ups from your healthcare provider.

One of the reasons for these symptoms could be Rheumatoid arthritis (RA) or Systemic lupus erythematosus (SLE). Both of these conditions have similarities in symptoms and can be difficult to diagnose. Sometimes, when there is a delay in diagnoses or underdiagnosed, the person is said to suffer from “rhupus.” Researchers refer to the overlap of conditions as rhupus syndrome, which features both RA and SLE.

What are SLE and Rheumatoid arthritis?

Both SLE and RA are autoimmune diseases. Autoimmune disorders occur when an individual’s own immune system attacks their healthy cells. Both SLE and RA are associated with triggering inflammations in the body.


Both SLE and RA symptoms tend to appear in younger age groups, i.e., 30-50 years in RA and 15-45 years in case of SLE.

Symptoms specific to SLE include:


Pain and swelling
in the joints

Butterfly shaped rash across the nose and cheeks



Sensitivity to sunlight
or fluorescent light

Hair loss

Ulcers in mouth
or nose

Numbness at the
tips of fingers & toes

Symptoms specific to RA include:


Pain, stiffness or swelling of the joints for more than 6 weeks

Pain in multiple joints

due to pain

Both conditions share similar symptoms (obvious similarity is joint pain and fatigue). 

Differences in SLE & RA symptoms

  • Lupus (SLE) affects joints, but mainly affects internal organs and your skin. It causes other complications such as seizures, increased blood clotting frequency, and kidney failure.
  • Above symptoms and complications are not associated with RA. It primarily attacks your joints in your fingers, wrists, knees and ankles. RA can cause inflammation in the lungs and around your heart, which is not the case with lupus.
  • Pain in the joints in case of RA is more in the mornings and subdues later, whereas the pain is consistent throughout the day in SLE.
  • In advanced stages, RA causes bone deformation (changes in bone shape) while SLE does not.


The cause of either of the diseases is not clear. It is said to be influenced by genetic, hormonal and environmental factors.

Diagnosis & Treatment

Initial stages of both SLE & RA can be confusing as they share common characteristics and mimics other conditions. This can cause delay in the diagnosis. Diagnosis can be done by

  • Careful examination of signs and symptoms (ruling out other conditions)
  • Combination of blood tests & urine tests

Treatment only aids in curing the symptoms such as inflammation and joint pains.

FAQ's :

Is SLE hereditary?

It is not a hereditary disease. However, if an immediate family member is having SLE, there is a risk that you may be affected as well. Example – a possibility between twin siblings.

Can gene studies cure SLE?

Genetic studies are being done towards genetic testing and to create personalised medicine for SLE.

What gene causes rheumatoid arthritis?

The most significant genetic risk factors for rheumatoid arthritis are variations in human leukocyte antigen (HLA) genes, especially the HLA-DR4 gene.

Which blood test can identify rheumatoid arthritis gene?

An anti-cyclic citrullinated peptide (anti-CCP/ACCP) test is an antibody test that looks for the presences of antibodies in a person and confirms rheumatoid arthritis.

How is gene therapy beneficial in reinstituting immune system?

The treatment involves collecting stem cells (cells which can develop into many different types of cells in the body) from a patient with immunodeficiency, correcting the gene in the cells, and then returning the corrected stem cells to the patient. Because gene therapy uses the patient’s own cells, there is no need to find a suitable donor. Only a few immunodeficiencies are being treated with this medication.

References :

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SLE/ Rheumatoid Arthritis

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