Treatments Focus

Cholesterol Metabolism

Cholesterol is a waxy, fat-like substance made in the liver and found in all the cells of the body. Cholesterol is very essential to the body and for maintenance of good health. It helps your body to make cell walls, tissues, hormones, vitamin D and bile acid. The cholesterol in your blood comes from two sources: the foods you eat and by your liver.
Cholesterol metabolism.

Metabolism can be defined as the chemical reactions that take place within each cell of a living organism which produce the energy needed to carry out vital functions such as moving, growing, etc.

Cholesterol metabolism is metabolized majorly in the liver and intestine in humans, although a small amount of cholesterol is lost through the skin during shedding of dead skin cells which is replaced with new cells. Your body needs adequate amount of cholesterol to be healthy.

Types of cholesterol

There are two main types of cholesterol: 

  • low-density lipoprotein (LDL), or “bad” cholesterol
  • high-density lipoprotein (HDL), or “good” cholesterol

High levels of HDL are desirable and are associated with good metabolic health, whereas high levels of LDL may increase risk of metabolic disorders.

Symptoms of cholesterol problems

High level of LDL in blood can increase the risk for other conditions such as:

High blood pressure

Angina (chest pain)


High cholesterol levels are common in people who are obese or have diabetes.


A cholesterol test is a blood test that measures the amount of each type of cholesterol and certain fats in your blood.

  • If you are 20 years or older, you should get checked every 4 to 6 years.
  • If you are obese, or diabetic or have any heart conditions – you will be asked for regular check-ups.


Lifestyle changes are the first choice of treatment for patients with disorders of cholesterol metabolism. Statins can also be used to bring down the levels of cholesterol.

The common measures to reduce cholesterol levels include:

  • Daily exercise
  • Quitting smoking
  • Alcohol restriction
  • Maintaining a healthy weight
  • Treating underlying conditions
  • Using medicines, if prescribed

FAQ's :

Are disorders of cholesterol metabolism genetic?

There is evidence that states that certain genetic mutations are involved in disorders related to cholesterol uptake, mobilization and cholesterol synthesis.

Is there genetic testing available for familial hypercholesterolemia (FH)?

Yes, there are genetic testing available that evaluate the presence of familial hypercholesterolemia.
Familial hypercholesterolemia is a gene alteration that is passed down from one or both parents (inherited), that causes high LDL cholesterol. This condition begins at birth and causes heart attacks at an early age. It is also called as familial hyperlipidaemia.

What is the difference between high cholesterol and familial hypercholesterolemia (FH)?

Anyone can develop high cholesterol as they age, but FH is an inherited genetic disorder.

What is familial hypertriglyceridemia? How is it treated?

Familial hypertriglyceridemia causes higher levels of triglycerides (a type of fat) in a person’s blood. It runs in families. Primary treatment includes lifestyle adjustments, diet modifications and drug therapy.


  1. Cholesterol level: Can it be too low? Mayo Clinic. Accessed on 19-05-2022
  2. High cholesterol. Mayo Clinic. Accessed on 19-05-2022
  3. Top 5 lifestyle changes to improve your cholesterol. Mayo Clinic. Accessed on 19-05-2022
  4. Cholesterol Metabolism. UTMB Health – University of Texas Medical Branch. Accessed on 19-05-2022

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