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World’s most trusted Companion Diagnostic testing for Personalized Cancer treatments

351 Clinically Significant Onco Genes

Trusted by over 10000+ oncologists globally

Sequencing depth of up-to 3000x with a total raw output of 10 GB per sample

Genomic testing for efficient cancer treatment & management

Offering world’s most trusted comprehensive genomic profiling test with in-depth insights on patients’ clinically relevant biomarkers and genomic alterations matching with FDA approved targeted therapies and immunotherapies.

OncoRx is a Next Generation Sequencing (NGS) based in vitro diagnostic test that uses targeted high throughput hybridization-based capture technology using DNA isolated from Formalin-Fixed Paraffin Embedded (FFPE) tumor tissue specimens and peripheral whole blood extracted circulating DNA.

It screens for Single Nucleotide Polymorphisms (SNPs), Insertion and Deletions (indels), Copy Number Alterations (CNAs) in 351 genes, select gene rearrangements, as well as genomic signatures including Homologous Recombination Repair (HRR) mutations, Microsatellite Instability (MSI) and Tumor Mutational Burden (TMB).

Empowering physicians and patients with actionable and prescriptive insights for navigating cancer care.

As a trusted partner of choice in companion diagnostics, GenepoweRx helps to advance Personalized Healthcare in India by delivering diagnostic confidence through a broad range of genomic tests. Our standardized, fully-automated and cloud-supported solutions enable rapid turnaround time, empowering physicians to make the right treatment decisions more quickly.

SNV

Indels

CNVs

Fusions

TMB

MSI

HRR

Highlights

Next Generation Sequencing using Illumina

The proprietary Indian population specific database of variants

Official partners of MSK’s Precision Oncology Knowledge Base

OncoRx is registered as Class – C medical devices with CDSCO (Reg. No: Uppalu-Hy-der-TE/M/IVD/008407)

Strict quality control measures at different stages of sample processing, data acquisition and analysis adhering to international clinical laboratory practice guidelines

The test is validated in-house and the mean sequencing depth of the OncoRx is up-to 3000x with a total raw data output of 10 GB per sample

High throughput NGS data analysis, curation, and interpretation of the mutations are performed by well-experienced clinical scientists/genome analysts and cancer genome experts

REPORT

In addition to FDA approved therapies, OncoRx also offers clinically actionable, personalized Pharmacogenomics (PGx) & Nutrigenomics (NGx) report.
PGx report helps in prescribing the right medication by studying the CPIC & PharmGkb approved Biomarkers. NGx profile helps in structuring a personalized nutrition regimen based on an individual’s genetic profile and metabolism.

Simplified oncologist friendly report

Clinically actionable prescriptive insights to oncologists

Information on available active clinical trials

Nutrigenomics (NGx)

Druggable alterations and their associated FDA approved therapies

personalized Pharmacogenomics (PGx)

Recommended targeted therapies & possible mechanisms of resistance

OncoKB Therapeutic Levels of Evidence

Standard Care

01

FDA-recognized biomarker predictive of response to an FDA-approved drug in this indication

Investigational

02

Standard care biomarker recommended by the NCCN or other professional guidelines predictive of response to an FDA-approved drug in this indication

3A

Compelling clinical evidence supports the biomarker as being predictive of response to a drug in this indication

3B

Standard care or investigational biomarker predictive of response to a FDA-approved or investigational drug in another indication

Hypothetical

4

Compelling biological evidence supports the biomarker as being predictive of response to a drug

Standard Care Resistance

R1

Standard care biomarker predictive of resistance to an FDA-approved drug in this indication

Investigational Resistance

R2

Compelling clinical evidence supports the biomarker as being predictive of resistance to a drug

Biomarkers & FDA-Approved Therapy

Non-Small Cell Lung Cancer

EGFR exon 19 deletions & EGFR exon 21 , L858R alterations

Gilotrif® (afatinib), Iressa® (gefitinib), Tagrisso® (osimertinib), or Tarceva®

EGFR exon 20 T790M alterations

Tagrisso® (osimertinib)

ALK rearrangements

Alecensa® (alectinib), Alunbrig® (brigatinib) Xalkori® (crizotinib), or Zykadia® (ceritinib)

BRAF V600E

Tafinlar® (dabrafenib) in combination with Mekinist® (trametinib)

MET single nucleotide variants (SNVs) and indels that lead to MET exon 14 skipping

TabrectaTM (capmatinib)

Breast Cancer

ERBB2 (HER2) amplification

Herceptin® (trastuzumab), Kadcyla® (ado trastuzumab-emtansine), or Perjeta® (pertuzumab)

PIK3CA C420R, E542K, E545A, E545D [1635G>T only], E545G, E545K, Q546E, Q546R, H1047L, H1047R, and H1047Y alterations

Piqray® (alpelisib)

Colorectal Cancer

KRAS wild-type (absence of mutations in codons 12 and 13)

Erbitux® (cetuximab)

KRAS wild-type (absence of mutations in exons 2, 3, and 4) and NRAS wild type (absence of mutations in exons 2, 3, and 4)

Vectibix® (panitumumab)

Ovarian Cancer

BRCA1/2 alterations

Lynparza® (olaparib) or Rubraca® (rucaparib)

Prostate Cancer

Homologous Recombination Repair (HRR) gene (BRCA1, BRCA2, ATM, BARD1, BRIP1, CDK12, CHEK1, CHEK2, FANCL, PALB2, RAD51B, RAD51C, RAD51D and RAD54L) alterations

Lynparza® (olaparib)

All Solid Tumors

TMB ≥ 10 mutations per megabase

Keytruda® (pembrolizumab)

NTRK1/2/3 fusions

Vitrakvi® (larotrectinib)

  • ABL1
  • AKT1
  • AKT2
  • AKT3
  • ALK
  • ALOX12B
  • AMER1
  • APC
  • AR
  • ARAF
  • ARFRP1
  • ARID1A
  • ASXL1
  • ATM
  • ATR
  • ATRX
  • AURKA
  • AURKB
  • AXIN1
  • AXL
  • BAP1
  • BARD1
  • BCL2
  • BCL2L1
  • BCL2L2
  • BCL6
  • BCOR
  • BCORL1
  • BRAF
  • BRCA1
  • BRCA2
  • BRD4
  • BRIP1
  • BTG1
  • BTG2
  • BTK
  • C11orf30
  • CALR
  • CARD11
  • CASP8
  • CBFB
  • CBL
  • CCND1
  • CCND2
  • CCND3
  • CCNE1
  • CD22
  • CD274
  • CD70
  • CD79A
  • CD79B
  • CDC73
  • CDH1
  • CDK12
  • CDK4
  • CDK6
  • CDK8
  • CDKN1A
  • CDKN1B
  • CDKN2A
  • CDKN2B
  • CDKN2C
  • CEBPA
  • CHEK1
  • CHEK2
  • CIC
  • CREBBP
  • CRKL
  • CSF1R
  • CSF3R
  • CTCF
  • CTNNA1
  • CTNNB1
  • CUL3
  • CUL4A
  • CVR1B
  • CXCR4
  • CYP17A1
  • DAXX
  • DDR1
  • DDR2
  • DIS3
  • DNMT3A
  • DOT1L
  • EED
  • EGFR
  • EP300
  • EPHA3
  • EPHB1
  • EPHB4
  • ERBB2
  • ERBB3
  • ERBB4
  • ERCC4
  • ERG
  • ERRFI1
  • ESR1
  • EZH2
  • FAM46C
  • FANCA
  • FANCC
  • FANCG
  • FANCL
  • FAS
  • FBXW7
  • FGF10
  • FGF12
  • FGF14
  • FGF19
  • FGF23
  • FGF3
  • FGF4 ID3
  • FGF6
  • FGFR1
  • FGFR2
  • FGFR3
  • FGFR4
  • FH
  • FLCN
  • FLT1
  • FLT3
  • FOXL2
  • FUBP1
  • GABRA6
  • GATA3
  • GATA4
  • GATA6
  • GID4
  • GNA11
  • GNA13
  • GNAQ
  • GNAS
  • GRM3
  • GSK3B
  • H3F3A
  • HDAC1
  • HGF
  • HNF1A
  • HRAS
  • HSD3B1
  • IDH1
  • IDH2
  • IGF1R
  • IKBKE
  • IKZF1
  • INPP4B
  • IRF2
  • IRF4
  • IRS2
  • JAK1
  • JAK2
  • JAK3
  • JUN
  • KDM5A
  • KDM5C
  • KDM6A
  • KDR
  • KEAP1
  • KEL
  • KIT
  • KLHL6
  • KMT2A
  • KMT2D
  • KRAS
  • LTK
  • LYN
  • MAF
  • MAP2K1
  • MAP2K2
  • MAP2K4
  • MAP3K1
  • MAP3K13
  • MAPK1
  • MCL1
  • MDM2
  • MDM4
  • MED12
  • MEF2B
  • MEN1
  • MERTK
  • MET
  • MITF
  • MKNK1
  • MLH1
  • MPL
  • MRE11A
  • MSH2
  • MSH3
  • MSH6
  • MST1R
  • MTAP
  • MTOR
  • MUTYH
  • MYC
  • MYCL
  • MYCN
  • MYD88
  • NBN
  • NF1
  • NF2
  • NFE2L2
  • NFKBIA
  • NKX2-1
  • NOTCH1
  • NOTCH2
  • NOTCH3
  • NPM1
  • NRAS
  • NT5C2
  • NTRK1
  • NTRK2
  • NTRK3
  • P2RY8
  • PALB2
  • PARK2
  • PARP1
  • PARP2
  • PARP3
  • PAX5
  • PBRM1
  • PDCD1
  • PDCD1LG2
  • PDGFRA
  • PDGFRB
  • PDK1
  • PIK3C2B
  • PIK3C2G
  • PIK3CA
  • PIK3CB
  • PIK3R1
  • PIM1
  • PMS2
  • POLD1
  • POLE R
  • PPARG
  • PPP2R1A
  • PPP2R2A
  • PRDM1
  • PRKAR1A
  • PRKCI
  • PTCH1
  • PTEN
  • PTOR
  • PTPN11
  • PTPRO
  • QKI
  • RAC1
  • RAD21
  • RAD51
  • RAD51B
  • RAD51C
  • RAD51D
  • RAD52
  • RAD54L
  • RAF1
  • RARA
  • RB1
  • RBM10
  • REL
  • RET
  • RICTOR
  • RNF43
  • ROS1
  • SDHA
  • SDHB
  • SDHC
  • SDHD
  • SETD2
  • SF3B1
  • SGK1
  • SMAD2
  • SMAD4
  • SMAR
  • CA4
  • SMARCB1
  • SMO
  • SNCAIP
  • SOCS1
  • SOX2
  • SOX9
  • SPEN
  • SPOP
  • SRC
  • STAG2
  • STAT3
  • STK11
  • SUFU
  • SYK
  • TBX3
  • TEK
  • TET2
  • TGFBR2
  • TIPARP
  • TNFAIP3
  • TNFRSF14
  • TP53
  • TSC1
  • TSC2
  • TYRO3
  • U2AF1
  • VEGFA
  • VHL
  • WHSC1
  • WHSC1L1
  • WT1
  • XPO1
  • XRCC2
  • ZNF217
  • ZNF703

  • ALK introns 18, 19
  • BRCA1 introns 2, 7, 8, 12, 16, 19, 20
  • ETV4 intron 8
  • EZR introns 9- 11
  • KIT intron 16
  • MYC intron 1
  • RET introns 7-11
  • SLC34A2 intron 4
  • BCL2 3’UTR
  • BRCA2 intron 2
  • ETV5 introns 6,
  • 7FGFR1 intron 1, 5, 17
  • KMT2A (MLL) introns
  • NOTCH2 intron 26
  • TERC ncRNA
  • PDGFRA introns 7, 9, 11
  • ROS1 introns 31-35
  • BCR introns 8, 13, 14
  • MSH2 intron
  • ETV6* introns 5, 6
  • FGFR2 intron 1, 17
  • NTRK1 introns
  • 11RAF1 introns 4-8
  • RSPO2 intron 1
  • TERT Promoter
  • BRAF introns 7-10
  • EWSR7-introns 7-13
  • FGFR3 intron 17
  • MYB intron 14
  • NTRK2 Intron 12
  • RARA intron 2
  • SDC4 intron 2
  • TMPRSS2 introns 1- 3

List of Genes Screened in OncoRX Mini -

  • ABL1
  • ABL2
  • ALK
  • APLNR
  • ATM
  • B2M
  • BARD1
  • BRAF
  • BRCA1
  • BRCA2
  • BRIP1
  • CD274
  • CD74
  • CDK12
  • CDKN2A
  • CDKN2B
  • CHEK1
  • CHEK2
  • EGFR
  • EML4
  • ERBB2
  • ERG
  • ETV1
  • ETV4
  • ETV5
  • ETV6
  • EZH2
  • FANCA
  • FANCC
  • FANCD2
  • FANCE
  • FANCF
  • FANCG
  • FANCL
  • FANCM
  • FGFR2
  • FGFR3
  • FOXA1
  • HLA-A
  • HLA-B
  • HLA-C
  • IDH1
  • IDH2
  • KIT
  • KRAS
  • MET
  • NAB2
  • NF1
  • NRAS
  • NRG1
  • NTRK1
  • NTRK2
  • NTRK3
  • PALB2
  • PDGFB
  • PDGFRA
  • PIK3CA
  • PTEN
  • RAD51B
  • RAD51C
  • RAD51D
  • RAD54L
  • RAF1
  • RB1
  • RET
  • ROS1
  • SLC34A2
  • SMARCB1
  • TERT
  • TP53
  • TSC1

  • ALK
  • BRAF
  • EGFR
  • ERBB2
  • KIT
  • MET
  • PDGFRA
  • PIK3CA
  • RET

  • EGFR
  • KRAS
  • NRAS
  • NTRK1
  • NTRK3
  • PDGFRA

OncoRx is intended as a companion diagnostic to identify patients who may benefit from treatment with the targeted therapies in accordance with the approved therapeutic product labeling.

Treating oncologists can also decide ideal candidates who can benefit from this test by means of immunotherapies, targeted therapies and personalized pharmacogenomic.

Tests
Next-Generation Sequencing
MSK(Memorial Sloan Kettering) Cancer Center Knowledge Base
Number of Genes
Depth
Homologous Recombination Repair (HRR)
Programmed Death Ligand - 1
Micro Satellite Instability (MSI)
Tumor Mutational Burden (TMB)
Pharmacogenomics
Nutrigenomics
Comprehensive Mini Condition Specific
351 71 16-24
3000X 1000X 1000X

Official Analytics partner

(Developed the first FDA approved Cancer Companion Diagnostic Test)

The world’s oldest and largest private cancer center, and GenePower(by K&H), partnered into collaboration that will utilize MSK’s clinical and research insights into gene mutations associated with solid tumors along with K&H proprietary database to provide accurate recommendations for Indian population .

Highlights

A directional test for tumor profiling enabling oncologists to predict response/ resistance to targeted and immuno-therapies for cancer patients over the traditional molecular testing.

Over 5600 genomic alterations covered-
We report substitutions, insertions, deletions, CNV, select rearrangements as well as genomic signatures including microsatellite instability and tumor mutation burden
We are the only company in Genomics space

lead by physicians in India.

Simplified reports
without ambiguous reporting is possible because we know exactly what a treating physician is looking for in the report
Open Discussion channel

between Oncologist, Pathologist and genomic specialist physician will lead to best treatment choices for the patient.

GenePower OncoRx uses targeted genomic sequencing and analysis to provide the physician with information on-

  • Druggable mutations in your patient for which targeted
    therapies are available.
  • Clinical trial match connector
  • Microsatellite Instabilty status (MSI)
  • Tumor Mutational Burden status (TMB)
  • Sample required- FFPE tissue sample
  • TAT(Turn Around Time)- 3- 4 weeks

Patients with stage 3 or stage 4 cancer who are looking to start targeted drug therapy.

When a patient is first diagnosed with cancer, it is suggested to take OncoRx test, prior to starting their chemotherapy treatment. The test enables the physician to identify the right drug regimen from the various FDA approved therapies. The response and management of the regimen is also analysed from the report enabling better decision-making for physicians.

OncoRx is India’s only test authenticated by FDA approved database developed by collecting longitudinal data over 20 years by clinicians/oncologists from MSK- Memorial Sloan Kettering Cancer Centre

Being the only company to be led by clinicians, we provide simple and precise reports that the clinicians are looking for when treating a patient. While maintaining precision in performance standards, decryption of data and quality control, the reports are automated with minimal turn-around-time.

OncoRx is testing solid tumours that uses next generation sequencing (NGS) to detect the four alterations known to drive cancer growth:

  1. SNP
  2. InDels (Insertions and Deletions)
  3. Copy number Variants (CNVs)
  4. Rearrangements or fusions

FAQs

A:  Targeted therapies act on specific molecular targets associated with cancer which have proven evidence for the desired response and predicted outcomes. Standard chemotherapy on the other hand, act on rapidly dividing normal and cancerous cells.

A: Onco mini test aids physicians for oncotherapy decision making by screening a short panel with 71 cancer genes covering:

Level 1- FDA approved drugs for FDA approved biomarkers

Level 2- NCCN ratified standard care biomarker response to FDA approved drugs

R1 candidate genes - Standard care bio-markers with resistance to FDA approved drugs

 

It is generally recommended for a patient who is opting for chemotherapy.

 

OncoRx Test screens a large panel of over 353 potential genes assisting in predicting outcomes of FDA approved drug response, resistance, immunotherapy selection and management. The biomarkers covered are:

Level 1, Level 2 and Level 3 (Biomarkers with compelling clinical evidence to FDA approved or investigational drugs )

 

 If a patient were to develop resistance of the ongoing chemotherapy it is recommended to choose OncoRx.

OncoRx is authenticated through collecting the world’s only FDA approved database which is developed by collecting real-time authorised data over 20+ years from Clinicians/ Oncologists of MSK. OncoRx also provides partnership opportunities to develop concrete databases, and 24/7 customer care representatives.

OncoRx provides the best second-line options for the patients as per the NCCN guidelines. We also provide clinical trial matches for the patients to enrol in leading institutions globally.

Single marker or Hotspot Mutation testing can detect only one alteration wherein OncoRx can provide insights on all four alterations known to drive cancer growth. The method of testing, therefore, takes a comprehensive approach to diagnosis and detailed reporting.

The biomarkers for non-small cell lung cancer, breast cancer, colorectal cancer, ovarian cancer, prostate cancer and all solid tumours are covered in the test. After identifying the specific biomarkers, the targeted FDA- approved therapies are selected.

An initial quality measure is performed in 3 days and processed only if the sample meets the OncoRx standards.

Helping us to deliver precise reports