Exemplary embodiments of the present disclosure are directed towards a system and method for processing genomic data using custom database in real-time to predict medical conditions of a user. The system comprising a next-generation sequencing machine configured to sequence one or more raw files and then send the sequenced files to a server. The system comprising a genomic data processing module configured to collects the one or more sequenced files from server and process the sequenced files for clinical significance of variants identified using a custom database. The genomic data processing module configured to process drug associations for the variants on a computing device and how effective associated drugs are for a user. The genomic data processing module gets the precise information on how the genetics of a specific area are occurred. The genomic data processing module generates preliminary reports on the computing device based on the precise information.