Paa (2009) – based on PROGERIA disorder
Storyline: Paa discusses genetic condition, Progeria aka Hutchinson-Gilford syndrome. This syndrome involves a single gene mutation in lamin A (LMNA) gene necessary for holding the centre of a cell together. It is an extremely rare and progressive disorder seen in children that causes accelerated aging, starting in their first two years of life.
Starring: Amitabh Bachchan, Abhishek Bachchan, Vidya Balan
Director & Writer: R. Balki
Storyline: Paa discusses genetic condition, Progeria aka Hutchinson-Gilford syndrome. This syndrome involves a single gene mutation in lamin A (LMNA) gene necessary for holding the centre of a cell together. It is an extremely rare and progressive disorder seen in children that causes accelerated aging, starting in their first two years of life. This movie depicts Auro (Amitabh Bachchan), a 13-year-old boy with Progeria syndrome, and how his life revolves around it and his family helping him cope with his condition.
Genetic test: It is performed using a blood sample that detects LMNA mutations that confirm the diagnosis of progeria.
Similar movies that illustrate progeria: The Curious Case of Benjamin Button (2008), and My Brilliant Life (2014).
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