CYP2E1 polymorphism is associated with colorectal cancer risk

A recent study revealed that CYP2E1 polymorphism rs2031920 is associated with an increased colorectal cancer (CRC) risk. The results of this study were published in the journal, Scientific Reports.

The study aimed to investigate the association between CYP2E1 polymorphisms and CRC risk. A meta-analysis study was carried out to evaluate the relationship of CYP2E1 rs2031920, rs3813867, and rs6413432 polymorphisms with the susceptibility to CRC. Web databases were searched to identify eligible studies that indicated the association between the CYP2E1 polymorphisms and CRC risk, which was then quantitatively synthesized using different genetic models.

Eighteen studies with 23,598 subjects were analyzed and a significant association was observed between rs2031920 and an increased CRC risk was observed in homozygous models, recessive models, and allele models. The results showed no significant associations for rs3813867 and rs6413432. Thus, it was concluded that only rs2031920 is associated with increased colorectal cancer risk.

References:

• Sharzehan, M. A. K., Sito, H., Abdullah, N., et al. (2022). Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis. Scientific reports. https://pubmed.ncbi.nlm.nih.gov/36418904/